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Related Concept Videos

Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Pigmentation01:19

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...

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Related Experiment Video

Updated: Jun 5, 2026

Precision Implementation of Minimal Erythema Dose (MED) Testing to Assess Individual Variation in Human Inflammatory Response
06:31

Precision Implementation of Minimal Erythema Dose (MED) Testing to Assess Individual Variation in Human Inflammatory Response

Published on: October 3, 2019

Erythema dyschromicum perstans.

Brook E Tlougan1, Mercedes E Gonzalez, Rajni V Mandal

  • 1Department of Dermatology, New York University, New York, NY, USA.

Dermatology Online Journal
|December 18, 2010
PubMed
Summary
This summary is machine-generated.

Erythema dyschromicum perstans (EDP) is a rare skin condition causing hyperpigmented patches. Narrow-band UV B phototherapy shows promise as an effective treatment for this disorder.

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Area of Science:

  • Dermatology
  • Pathology

Background:

  • Erythema dyschromicum perstans (EDP) is a rare idiopathic disorder characterized by progressive skin hyperpigmentation.
  • The exact etiology of EDP remains unknown, with various potential associations reported in medical literature.

Observation:

  • A 39-year-old Hispanic male presented with widespread, symmetric, hyperpigmented macules and patches.
  • Lesions were oval-to-circular, brown-gray-blue, discrete to coalescing, predominantly on the extremities, trunk, neck, and face.
  • Many lesions exhibited an associated annular erythematous border, indicative of an inflammatory phase.

Findings:

  • Histopathology revealed interface dermatitis, thin lichenoid infiltrates, superficial perivascular infiltrates, and dermal melanophages.
  • These findings were consistent with the diagnosis of erythema dyschromicum perstans.
  • The presence of an erythematous rim during the inflammatory phase is a key diagnostic feature distinguishing EDP.

Implications:

  • Currently, no consistently effective treatment exists for erythema dyschromicum perstans.
  • Narrow-band UV B phototherapy is presented as a potentially effective therapeutic option.
  • This case highlights the successful application of narrow-band UV B in managing EDP, offering hope for future treatment strategies.