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Updated: Jun 5, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

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Published on: July 19, 2019

Late onset multiple sclerosis.

M Arias1, D Dapena, S Arias-Rivas

  • 1Servicio de Neurología, Complexo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, La Coruña, España. mariasg@meditex.es

Neurologia (Barcelona, Spain)
|December 18, 2010
PubMed
Summary
This summary is machine-generated.

Late onset multiple sclerosis (LOMS) often presents with motor or multisystem deficits and progresses primarily. Diagnosis is frequently delayed, leading to significant disability upon identification.

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Area of Science:

  • Neurology
  • Neuroimmunology
  • Clinical Neuroscience

Background:

  • Late onset multiple sclerosis (LOMS) is an uncommon and challenging neurological condition.
  • Characterized by initial symptoms after age 50, LOMS diagnosis is often delayed and poorly understood.

Purpose of the Study:

  • To investigate the characteristics of LOMS patients.
  • To analyze demographic data, initial symptoms, diagnostic delays, and disease progression in LOMS.

Main Methods:

  • Retrospective review of 18 LOMS patients.
  • Analysis of clinical presentation, Expanded Disability Status Scale (EDSS), disease course, and diagnostic test results (MRI, CSF, VEP).

Main Results:

  • Most frequent initial symptoms included motor deficits (33%) and multisystem deficits (33%).
  • Primary progressive MS (62%) was the predominant clinical course.
  • Diagnosis delay exceeded 5 years in two-thirds of cases, with high initial EDSS scores.

Conclusions:

  • LOMS typically follows a primary progressive course with motor/multisystem onset.
  • Delayed diagnosis in LOMS leads to substantial disability.
  • Cerebrovascular disorders and cervical myelopathy are key differential diagnoses for LOMS.