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Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus

Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus

Published on: March 8, 2012

[Adverse effects of the human papillomavirus vaccine]

M Amparo Torrecilla Rojas¹, Miguel Pedregal González, Fermín García Rodríguez

¹Distrito Condado-Campiña, Huelva, Spain. amparotorrecilla@andaluciajunta.es

Atencion Primaria

|December 18, 2010

Abstract

Objective:

To describe the most frequent adverse reactions produced by the human papillomavirus (HPV) vaccine.

Design:

Cross-sectional descriptive study using a telephone survey.

Setting:

A province in the Andalusian Public Health System.

Participants:

Females vaccinated against HPV in Andalusia, selected by simple random sampling representative of the province.

Main Measurements:

A total of 3,135 telephone calls were made by the public service "Health Answers" using telephone operators supervised by health personnel.

Results:

Of the 2,880 calls that fulfilled the inclusion criteria, 1,207 people (41.9% response) took part in the survey. Of the 2,124 surveys made there was some type of adverse reaction (fever, inflammation, pain or rash) in 467 doses (22%): 6.6% was fever, 49.5% inflammation, 72.4% pain, and 6% a rash.

Conclusions:

It can be said that HPV vaccine is safe, which is in agreement with that published in the summary of the product characteristics and in the literature.

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