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Brachytherapy in lip carcinoma: long-term results
Mireille Guibert1, Isabelle David, Sébastien Vergez
1Department of Head and Neck Surgery, Larrey Hospital, Toulouse, France. mireilleguib@voila.fr
International Journal of Radiation Oncology, Biology, Physics
|December 18, 2010
Summary
Low-dose-rate brachytherapy effectively treats lip cancers, offering excellent local control and relapse-free survival. This radiation therapy provides significant cosmetic and functional benefits with minimal side effects.
Area of Science:
- Oncology
- Radiation Oncology
- Dermatology
Background:
- Lip cancers, including squamous cell and basal cell carcinomas, require effective treatment strategies.
- Brachytherapy is a localized radiation therapy technique used for various cancers.
Purpose of the Study:
- To evaluate the effectiveness of low-dose-rate brachytherapy for local control and relapse-free survival in lip carcinomas.
- To compare outcomes between skin and mucosal lip cancer groups.
Main Methods:
- Retrospective analysis of 172 patients treated with low-dose-rate brachytherapy (iridium 192 wires, Paris system) between 1990-2008.
- Average delivered dose of 65 Gy.
- Follow-up averaged 5.4 years.
Main Results:
- 8-year relapse-free survival was 80% overall (85% for skin, 75% for mucosal).
- Local recurrences: 5 in skin, 10 in mucosal.
- Lymph node recurrences: 1 in skin, 5 in mucosal.
- Excellent functional (99%) and cosmetic (92%) results with Grade 2 maximal toxicity.
Conclusions:
- Low-dose-rate brachytherapy is an effective standalone treatment for T1/T2 lip carcinomas.
- Achieves excellent local control and relapse-free survival.
- Offers significant cosmetic and functional benefits with a high rate of no side effects (91%).
