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γ-Adducin stimulates the thiazide-sensitive NaCl cotransporter

Henrik Dimke1, Pedro San-Cristobal, Mark de Graaf

  • 1Department of Physiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

Journal of the American Society of Nephrology : JASN
|December 18, 2010
PubMed
Summary

Gamma-adducin interacts with and stimulates the thiazide-sensitive NaCl cotransporter (NCC), a key regulator of blood pressure. This interaction influences NCC activity by altering its phosphorylation state, impacting renal salt transport and blood pressure homeostasis.

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