Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Evidence for Evolution02:55

The Evidence for Evolution

Genetic variations accumulating within populations over generations give rise to biological evolution. Evolutionary changes can result in the formation of novel varieties and entire new species. These changes are responsible for the diverse forms of life inhabiting the planet. The evidence for evolution suggests that all living organisms descended from common ancestors.The collection of fossils within sedimentary rocks give a record of common ancestry and often depicts the history of evolution.
Methods of Documentation V: CBE01:23

Methods of Documentation V: CBE

Charting by Exception, or CBE, is a method of documentation used in healthcare, particularly in nursing, that focuses on documenting only significant or abnormal findings rather than recording every detail. This approach aims to streamline the documentation process, improve efficiency, and ensure that healthcare providers can quickly identify deviations from normalcy in patient assessments.
In CBE, healthcare professionals establish predefined standards of practice that define what constitutes...
Confirmation Biases01:31

Confirmation Biases

The confirmation bias is the tendency to focus on information that confirms our existing beliefs and ignore information that is inconsistent with our expectations. For example, if you think that your professor is not very nice, you notice all of the instances of rude behavior exhibited by the professor while ignoring the countless pleasant interactions he is involved in on a daily basis. Have you ever fallen prey to the confirmation bias, either as the source or target of such bias?
Naturalistic Observations02:30

Naturalistic Observations

If you want to understand how behavior occurs, one of the best ways to gain information is to simply observe the behavior in its natural context. However, people might change their behavior in unexpected ways if they know they are being observed. How do researchers obtain accurate information when people tend to hide their natural behavior? As an example, imagine that your professor asks everyone in your class to raise their hand if they always wash their hands after using the restroom. Chances...
Criteria for Causality: Bradford Hill Criteria - II01:28

Criteria for Causality: Bradford Hill Criteria - II

The Bradford Hill criteria serve as guidelines for establishing causative links in epidemiological research. Beyond Strength, Consistency, Specificity, and Temporality, key criteria also include Biological Gradient, Plausibility, Coherence, Experiment, and Analogy. These principles assist scientists in assessing the likelihood of causation in complex biological contexts. Below is a summary of these concepts:
Bias in Epidemiological Studies01:29

Bias in Epidemiological Studies

Biases can arise at various stages of research, from study design and data collection to analysis and interpretation. Recognizing and addressing these biases is essential to ensure the validity and reliability of epidemiological findings.Broadly speaking, biases in epidemiology fall into three main categories: selection bias, information bias, and confounding. A more detailed description of possible biases is:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Human Development Index and outcomes in older critically ill patients: A European multicentre study.

Annals of intensive care·2026
Same author

Sex and 30-day mortality in elderly critically Ill adults: A frailty-adjusted multinational analysis with frequentist and bayesian estimates.

European journal of internal medicine·2026
Same author

Publisher Correction: Surviving Sepsis Campaign: international guidelines for management of sepsis and septic shock 2026.

Intensive care medicine·2026
Same author

The customization of general outcome prediction models: a statistical exercise or a necessity?

Critical care science·2026
Same author

Executive Summary: Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2026.

Critical care medicine·2026
Same author

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2026.

Critical care medicine·2026

Related Experiment Video

Updated: Jun 5, 2026

Holistic Facial Composite Creation and Subsequent Video Line-up Eyewitness Identification Paradigm
09:49

Holistic Facial Composite Creation and Subsequent Video Line-up Eyewitness Identification Paradigm

Published on: December 24, 2015

Evidence should not be viewed in isolation.

Rui Moreno1, Andrew Rhodes

  • 1Unidade de Cuidados Intensivos Polivalente, Hospital de St. António dos Capuchos, Centro Hospitalar de Lisboa Central, Lisboa, Portugal. r.moreno@mail.telepac.pt

Critical Care Medicine
|December 18, 2010
PubMed
Summary
This summary is machine-generated.

Recent clinical trials show improved outcomes for critically ill patients using intervention bundles. However, rapid implementation without considering context risks patient harm due to efficacy-effectiveness differences.

More Related Videos

A Psychophysics Paradigm for the Collection and Analysis of Similarity Judgments
08:12

A Psychophysics Paradigm for the Collection and Analysis of Similarity Judgments

Published on: March 1, 2022

Related Experiment Videos

Last Updated: Jun 5, 2026

Holistic Facial Composite Creation and Subsequent Video Line-up Eyewitness Identification Paradigm
09:49

Holistic Facial Composite Creation and Subsequent Video Line-up Eyewitness Identification Paradigm

Published on: December 24, 2015

A Psychophysics Paradigm for the Collection and Analysis of Similarity Judgments
08:12

A Psychophysics Paradigm for the Collection and Analysis of Similarity Judgments

Published on: March 1, 2022

Area of Science:

  • Critical care medicine
  • Clinical trial methodology
  • Evidence-based practice

Background:

  • Decades of negative trials in critical illness contrasted with recent positive intervention studies.
  • Positive findings led to the development of care bundles for critically ill patients.
  • Rapid adoption of bundles often overlooks the original study context and efficacy-effectiveness differences.

Purpose of the Study:

  • To critically evaluate the implementation of care bundles in critical illness.
  • To highlight the risks associated with bypassing bundle validation for broader application.
  • To address the "two-weight, two-measures" issue in clinical practice and quality control.

Main Methods:

  • Review of recent multicenter, randomized, placebo-controlled, double-blind clinical trials.
  • Analysis of the transition from individual intervention studies to bundled care packages.
  • Examination of the implications of applying evidence generated in specific contexts to diverse patient populations.

Main Results:

  • A trend towards positive outcomes with intervention bundles in critical care.
  • Concerns regarding the unvalidated, widespread implementation of these bundles.
  • Potential for misuse of bundle tools in quality control and performance evaluation.

Conclusions:

  • The rapid implementation of care bundles risks patient harm by disregarding original study contexts.
  • Validation of bundles across diverse populations is crucial before widespread adoption.
  • Resolving the "two-weight, two-measures" disparity is essential to maintain patient safety and professional integrity.