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Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure

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Related Experiment Video

Updated: Jun 5, 2026

Delivery of In Vivo Acute Intermittent Hypoxia in Neonatal Rodents to Prime Subventricular Zone-derived Neural Progenitor Cell Cultures

Delivery of In Vivo Acute Intermittent Hypoxia in Neonatal Rodents to Prime Subventricular Zone-derived Neural Progenitor Cell Cultures

Published on: November 2, 2015

Hyperoxia may be beneficial.

Enrico Calzia¹, Pierre Asfar, Balász Hauser

¹Sektion Anästhesiologische Pathophysiologie und Verfahrensentwicklung, Klinik für Anästhesiologie, Universitätsklinikum, Ulm, Germany.

Critical Care Medicine

|December 18, 2010

Summary

This summary is machine-generated.

Mechanical ventilation with 100% oxygen may benefit septic shock patients by improving oxygen delivery and reducing infection risk. Further clinical trials are needed to confirm the safety and efficacy of this supportive measure.

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Isolation of Pulmonary Artery Smooth Muscle Cells from Neonatal Mice

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Delivery of In Vivo Acute Intermittent Hypoxia in Neonatal Rodents to Prime Subventricular Zone-derived Neural Progenitor Cell Cultures

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Isolation of Pulmonary Artery Smooth Muscle Cells from Neonatal Mice

Isolation of Pulmonary Artery Smooth Muscle Cells from Neonatal Mice

Published on: October 19, 2013

Area of Science:

Critical Care Medicine
Pulmonology
Sepsis Research

Background:

Current mechanical ventilation practices aim for minimal supplemental oxygen.
Early goal-directed therapy for septic shock optimizes oxygen delivery without hyperoxia.
Long-term oxygen exposure can cause toxicity, but short-term use is debated.

Purpose of the Study:

To evaluate the potential benefits of using 100% oxygen during mechanical ventilation in the initial 12-24 hours of septic shock.
To explore whether hyperoxia can counteract negative effects of septic shock and anesthesia.

Main Methods:

Review of existing evidence on oxygen toxicity and hyperoxia effects.
Comparison of ventilation with 100% oxygen in septic shock versus healthy individuals and anesthesia patients.
Analysis of physiological effects of hyperoxia, including vasoconstriction and organ perfusion.

Main Results:

Ventilation with 100% oxygen does not worsen intrapulmonary shunt in hyperinflammatory states with lung-protective ventilation.
Short-term hyperoxia (12-24 hours) has negligible direct oxygen toxicity.
Hyperoxia may reduce vasopressor needs, improve organ perfusion, and possess antibiotic properties, reducing infections.

Conclusions:

Mechanical ventilation with 100% oxygen is proposed as a supportive measure for the first 12-24 hours of septic shock.
Hyperoxia may counteract hypotension, improve perfusion, and reduce infection rates in septic shock.
Controlled clinical trials are essential to validate the safety and efficacy of perioperative hyperoxia in septic shock.