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BacT/Alert: an automated colorimetric microbial detection system.

T C Thorpe1, M L Wilson, J E Turner

  • 1Organon Teknika Corporation, Durham, North Carolina 27704.

Journal of Clinical Microbiology
|July 1, 1990
PubMed
Summary
This summary is machine-generated.

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The BacT/Alert system reliably detects bacteria and fungi using CO2 colorimetric detection. Initial trials show it is comparable to existing systems for blood microbial detection.

Area of Science:

  • Clinical microbiology
  • Medical diagnostics
  • Biotechnology

Background:

  • Automated microbial detection systems are crucial for timely diagnosis.
  • Existing systems have varying sensitivities and detection methods.
  • The BacT/Alert system offers a novel colorimetric approach.

Purpose of the Study:

  • To evaluate the performance of the BacT/Alert microbial detection system.
  • To assess its reliability in growing and detecting various microorganisms.
  • To compare its efficacy against established systems in blood cultures.

Main Methods:

  • Evaluation of BacT/Alert media, sensor, detection system, and algorithm.
  • Limited pilot clinical trial using a prototype research instrument.
  • Comparison with the radiometric BACTEC 460 system for blood microbial detection.

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Main Results:

  • The BacT/Alert system reliably grows and detects a wide range of bacteria and fungi.
  • The system demonstrated comparable performance to the BACTEC 460 system in a pilot clinical trial.
  • Colorimetric CO2 detection proved effective for microbial identification.

Conclusions:

  • The BacT/Alert system shows promise as a reliable automated microbial detection method.
  • Further large-scale clinical trials are warranted to compare BacT/Alert with other commercial systems.
  • The system's performance suggests potential for improved clinical diagnostics.