Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Drug resistance in tuberculosis.

I O al-Orainey1

  • 1Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Journal of Chemotherapy (Florence, Italy)
|June 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Improved sensitivity for detection of tuberculosis cases by a modified Anda-TB ELISA test.

Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2000
Same author

Does the protective effect of neonatal BCG correlate with vaccine-induced tuberculin reaction?

American journal of respiratory and critical care medicine·1995
Same author

Visceral leishmaniasis in Gizan, Saudi Arabia.

Annals of Saudi medicine·1994
Same author

Nationwide community survey of tuberculosis epidemiology in Saudi Arabia.

Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·1993
Same author

Detection of mycobacterial antigens in sputum by an enzyme immunoassay.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·1992
Same author

The significance of positive Mantoux reactions in BCG-vaccinated children.

Tubercle·1991

Antituberculosis drug resistance emerges from pre-existing bacterial mutants. Rifampicin resistance significantly impacts treatment success, highlighting the need for combination therapy to preserve drug efficacy.

Area of Science:

  • Microbiology
  • Pharmacology
  • Infectious Diseases

Background:

  • Antituberculosis drug resistance arises from pre-existing chromosomal mutations in bacterial populations.
  • Resistance emergence is exacerbated by large bacterial populations or monotherapy.
  • Certain potent drugs like rifampicin, isoniazid, and streptomycin can prevent resistance development.

Purpose of the Study:

  • To investigate the impact of drug resistance on the efficacy of short-course chemotherapy for tuberculosis.
  • To evaluate the role of specific drug resistances (isoniazid, streptomycin, rifampicin) in treatment outcomes.
  • To provide recommendations for controlling drug resistance and maintaining successful tuberculosis treatment.

Main Methods:

  • Analysis of resistance patterns in tuberculosis bacterial populations.

Related Experiment Videos

  • Evaluation of treatment response in patients undergoing short-course chemotherapy with varying drug resistance profiles.
  • Assessment of the influence of isoniazid, streptomycin, and rifampicin resistance on treatment failure rates.

    • Main Results:

    • Resistance to isoniazid and streptomycin showed minimal impact on short-course chemotherapy response.
    • Rifampicin resistance was strongly associated with a high rate of treatment failure.
    • Pre-existing chromosomal mutations are the origin of drug resistance in tuberculosis.

    Conclusions:

    • Controlling drug resistance is crucial for the sustained success of short-course chemotherapy.
    • Restricting rifampicin use to combination drug regimens is essential to mitigate resistance development.
    • Maintaining the efficacy of essential antituberculosis drugs like rifampicin is paramount for global tuberculosis control efforts.