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Updated: Jun 5, 2026

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
Atypical dengue Fever in a splenectomized boy with glucose-6- phosphodehydrogenase deficiency and thalassemia
Veronique Dinand1, Vera Metzler, Satya Prakash Yadav
1Pediatric Hematology Oncology and BMT Unit, Department of Pediatrics, Sir Ganga Ram Hospital, Rajender Nagar, New Delhi, 110060, India.
Abstract:
The authors report the difficulties faced in diagnosing and managing dengue fever in a 16-year-old boy suffering from glucose-6-phosphodehydrogenase deficiency and thalassemia intermedia 2 months after splenectomy. Prolonged fever, hepatomegaly, decrease in hematocrit were observed. Negative blood cultures, normal procalcitonin and persistent fever despite broad-spectrum antibiotics decreased the possibility of bacterial sepsis. Platelet count decreased to 58,000/μL on the day of defervescence and dengue IgM serology was positive. The course of dengue fever can be very different if underlying thalassemia, splenectomy and/or G-6PD deficiency are present.
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