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Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

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Related Experiment Video

Updated: Jun 5, 2026

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing (Neo)adjuvant Therapies
07:15

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing (Neo)adjuvant Therapies

Published on: July 28, 2020

Prognosticators in thigh soft tissue sarcomas.

Anne E Newcomer1, Diane Dylinski, Brian P Rubin

  • 1Case Western Reserve University Medical School, Cleveland, Ohio, USA.

Journal of Surgical Oncology
|December 18, 2010
PubMed
Summary
This summary is machine-generated.

This study reveals that blood transfusions, smoking history, and radiation therapy are risk factors for sarcoma progression and death. The site of the initial biopsy also impacts recurrence rates in sarcoma patients.

More Related Videos

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
07:55

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

Published on: April 11, 2018

Related Experiment Videos

Last Updated: Jun 5, 2026

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing (Neo)adjuvant Therapies
07:15

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing (Neo)adjuvant Therapies

Published on: July 28, 2020

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
07:55

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

Published on: April 11, 2018

Area of Science:

  • Oncology
  • Surgical Oncology
  • Hematology

Background:

  • The prognostic roles of smoking history, family cancer history, and leukoreduced blood transfusions in sarcoma patients remain unexamined.
  • The impact of preoperative radiation on blood loss in sarcoma patients has not been previously investigated.

Purpose of the Study:

  • To investigate the influence of patient-specific factors, including smoking history, family cancer history, and blood transfusion parameters, on sarcoma outcomes.
  • To evaluate the effect of preoperative radiation therapy on blood loss and overall prognosis in sarcoma patients.

Main Methods:

  • A retrospective analysis of 77 patients with non-metastatic, non-recurrent thigh sarcomas treated surgically.
  • Patient variables assessed included family cancer history, perioperative transfusion history, smoking history, and radiation history.
  • Median follow-up for survivors was 3.2 years.

Main Results:

  • Tumor grade, transfusion of >3 units of blood, and pre- or post-operative radiation therapy were identified as risk factors for distant metastasis.
  • Tumor grade, positive smoking history, and transfusion of >3 units of non-leukoreduced blood were risk factors for all-cause mortality.
  • Close family history of cancer correlated with high-grade sarcoma, and neoadjuvant radiotherapy correlated with increased blood transfusion volume.

Conclusions:

  • This study highlights novel associations between blood transfusion practices, family cancer history, and the site of initial biopsy with sarcoma patient outcomes.
  • Findings suggest that transfusion volume and type, smoking status, and radiation exposure are significant prognostic indicators in sarcoma.
  • The location of the initial biopsy may influence sarcoma recurrence rates, indicating the importance of specialized treatment centers.