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Updated: Jun 5, 2026
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Isolation, Characterization, And High Throughput Extracellular Flux Analysis of Mouse Primary Renal Tubular Epithelial Cells
Published on: June 20, 2018
[TRPP subfamily and kidney diseases]
Jie Zhao1, Wei Yang, Jian-hong Luo
1Institute of Neuroscience, College of Medicine, Zhejiang University, Hangzhou 310058, China.
Summary
The TRPP subfamily, crucial for kidney function and taste, is reviewed here. Abnormalities in these transient receptor potential channels are linked to polycystic kidney diseases.
Area of Science:
- Molecular Biology
- Physiology
- Genetics
Context:
- The Transient Receptor Potential (TRP) channel superfamily comprises diverse ion channels.
- The TRPP subfamily, a key component of the TRP family, plays significant roles in cellular physiology.
- Dysregulation of TRPP channels is implicated in various pathologies, notably polycystic kidney diseases.
Purpose:
- To review recent research on the TRPP subfamily of ion channels.
- To elucidate the structural and functional characteristics of TRPP channels.
- To explore the association between TRPP subfamily dysfunction and the pathogenesis of polycystic kidney diseases.
Summary:
- The TRPP subfamily possesses a characteristic structure including six transmembrane domains and ankyrin repeats.
- TRPP channels (e.g., TRPP2, TRPP3, TRPP5) exhibit distinct activation modes and functions.
- This subfamily is integral to physiological processes and gustation, with structural anomalies leading to polycystic kidney conditions.
Impact:
- Provides a comprehensive overview of current TRPP subfamily research.
- Highlights the link between TRPP channel structure/function and polycystic kidney disease development.
- Offers insights into potential therapeutic targets for kidney disorders.
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