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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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CNS Depressants: Alcohol and Nicotine

Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...

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Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
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Alcohol use disorders in geriatrics.

Raj K Kalapatapu1, Philip Paris, Judith A Neugroschl

  • 1Department of Psychiatry, Columbia University/New York State Psychiatric Institute, New York, NY 10032, USA. kalapat@pi.cpmc.columbia.edu

International Journal of Psychiatry in Medicine
|December 21, 2010
PubMed
Summary

This review addresses alcohol use disorders in older adults, detailing detection, treatment planning, and management strategies for primary care physicians. It emphasizes comprehensive care to reduce morbidity and mortality in this vulnerable population.

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Area of Science:

  • Geriatric Medicine
  • Addiction Psychiatry
  • Public Health

Background:

  • Alcohol use disorders (AUDs) significantly impact geriatric health, causing substantial morbidity and mortality.
  • Older adults present unique challenges in the presentation and management of AUDs.

Purpose of the Study:

  • To provide primary care physicians with a framework for managing geriatric patients with alcohol abuse.
  • To review key aspects of AUDs in the elderly, from detection to comprehensive treatment.

Main Methods:

  • A review of current literature on alcohol use disorders in the geriatric population.
  • Illustration through a hypothetical case study of a geriatric patient over four office visits.

Main Results:

  • Discussion covers the range of alcohol use, epidemiology, and the medical/psychiatric impact of AUDs in older adults.
  • Explores effective detection methods, comprehensive treatment planning, psychotherapy, and medication management.

Conclusions:

  • Primary care physicians can play a crucial role in identifying and managing AUDs in geriatric patients.
  • Availability of resources for clinicians and patients is vital for successful intervention and improved outcomes.