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Related Experiment Video

Updated: Jun 5, 2026

Isolation, Culture, and Characterization of Prostate Cancer-Associated Fibroblasts
09:43

Isolation, Culture, and Characterization of Prostate Cancer-Associated Fibroblasts

Published on: August 1, 2025

Thrombin expression in prostate: a novel finding.

Manish Kohli1, Karin Williams, Jorge L Yao

  • 1Department of Oncology, Mayo Clinic, Rochester, Minnesota 55905, USA. kohli.manish@mayo.edu

Cancer Investigation
|December 21, 2010
PubMed
Summary
This summary is machine-generated.

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Prostate cancer tissue contains significant amounts of thrombin, a key coagulation protein. This finding suggests potential for developing novel antithrombin therapies targeting prostate cancer.

Area of Science:

  • Biochemistry
  • Oncology
  • Molecular Biology

Background:

  • Coagulation protein expression varies across different cancer types.
  • Thrombin expression in prostate tissue has not been extensively studied.

Purpose of the Study:

  • To evaluate the expression and localization of thrombin in prostate tissue.
  • To explore the potential of thrombin as a therapeutic target in prostate cancer.

Main Methods:

  • Quantitative real-time PCR for mRNA expression in fresh tissue.
  • In situ hybridization (ISH) for tissue localization.
  • Immunohistochemistry on prostate tissue microarrays for protein detection.

Main Results:

  • Thrombin mRNA was detected in prostate cancer tissue, localized to epithelium and stroma.

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miRNA Expression Analyses in Prostate Cancer Clinical Tissues
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Last Updated: Jun 5, 2026

Isolation, Culture, and Characterization of Prostate Cancer-Associated Fibroblasts
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Isolation, Culture, and Characterization of Prostate Cancer-Associated Fibroblasts

Published on: August 1, 2025

In vitro Method to Observe E-selectin-mediated Interactions Between Prostate Circulating Tumor Cells Derived From Patients and Human Endothelial Cells
11:56

In vitro Method to Observe E-selectin-mediated Interactions Between Prostate Circulating Tumor Cells Derived From Patients and Human Endothelial Cells

Published on: May 15, 2014

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
11:29

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

  • Thrombin protein was found in the stroma of both benign and malignant prostate epithelium.
  • Significant difference in thrombin detection between benign and malignant epithelium (p <.05).

    • Conclusions:

    • Prostate tissue serves as a substantial reservoir for thrombin.
    • The presence of thrombin in prostate tissue indicates potential for antithrombin-based cancer therapies.