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Updated: Jun 5, 2026

A Microplate Assay to Assess Chemical Effects on RBL-2H3 Mast Cell Degranulation: Effects of Triclosan without Use of an Organic Solvent

A Microplate Assay to Assess Chemical Effects on RBL-2H3 Mast Cell Degranulation: Effects of Triclosan without Use of an Organic Solvent

Published on: November 1, 2013

Triclosan - an update.

S Saleh¹, R N S Haddadin, S Baillie

¹School of Pharmacy, Applied Sciences University, Amman, Jordan.

Letters in Applied Microbiology

|December 21, 2010

Summary

This summary is machine-generated.

Triclosan inhibits bacterial enoyl-acyl carrier protein reductase, raising concerns about induced resistance. This review updates knowledge on triclosan resistance and cross-resistance mechanisms in bacteria.

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A Microplate Assay to Assess Chemical Effects on RBL-2H3 Mast Cell Degranulation: Effects of Triclosan without Use of an Organic Solvent

A Microplate Assay to Assess Chemical Effects on RBL-2H3 Mast Cell Degranulation: Effects of Triclosan without Use of an Organic Solvent

Published on: November 1, 2013

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Published on: December 22, 2023

Area of Science:

Microbiology
Biochemistry
Pharmacology

Background:

Triclosan's 1998 discovery revealed its action as an inhibitor of bacterial enoyl-acyl carrier protein reductase.
This mechanism sparked debate regarding triclosan's potential to induce bacterial resistance and cross-resistance.

Purpose of the Study:

To provide an updated review of research on triclosan resistance and cross-resistance.
To consolidate recent findings following the 2004 review of the topic.

Main Methods:

Literature review of recent scientific research.
Analysis of studies investigating triclosan's mode of action and resistance development.

Main Results:

Recent research continues to explore the mechanisms by which bacteria may develop resistance to triclosan.
Cross-resistance patterns associated with triclosan are an ongoing area of investigation.

Conclusions:

Understanding triclosan's impact on bacterial resistance is crucial for its continued use.
Further research is needed to fully elucidate the implications of triclosan resistance and cross-resistance.