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Influence of central and peripheral norepinephrine on the antibody response
1Department of Microbiology and Immunology, A.B. Chandler Medical Center, University of Kentucky, Lexington.
Abstract:
This paper intends to study the effect on the antibody response of profound, or mild variations of (central and peripheral) noradrenergic activity. An intraperitoneal injection of 6-hydroxydopamine (100 mg/kg) at the time of immunization impaired the anti-sheep-erythrocyte antibody response in both normal mice and in mice previously denervated with 6-hydroxydopamine; treatment with 6-hydroxydopamine, 7 days before immunization, did not affect the response. This suggests either a direct effect of the neurotoxin on the antibody response or an indirect effect via denervation and supersensitivity. Therapeutic doses of guanethidine (0.5-2.5 mg/kg) which do not damage the adrenergic axons, affected marginally and transiently the antibody response to sheep erythrocytes. Intracisternal injection of 6-hydroxydopamine (a 75-ug pulse, or three 25-ug pulses), DSP4 (a 75-ug pulse), or guanethidine (three 100-ug pulses) did not alter either the anti-trinitrophenyl natural-antibody response or the anti-sheep-erythrocyte antibody response. Swimming (at 32 degrees C) transiently and slightly enhanced the anti-sheep-erythrocyte (IgM) antibody response. It is proposed that the physiological fluctuations in the level of (central or peripheral) noradrenergic activity transiently and minimally influence the antibody response.
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