Adverse reactions to injectable soft tissue fillers
Luis Requena1, Celia Requena, Lise Christensen
1Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain. lrequena@fjd.es
Journal of the American Academy of Dermatology
|December 21, 2010
Summary
Dermal fillers for wrinkle treatment can cause adverse reactions. Histopathology is crucial for identifying filler types and managing complications, especially with long-lasting agents.
Area of Science:
- Dermatology
- Plastic Surgery
- Pathology
Background:
- Dermal fillers are widely used for wrinkle treatment and soft tissue augmentation.
- No ideal filler exists; all carry risks of adverse reactions.
- Complications from fillers can range from temporary to severe and long-lasting.
Purpose of the Study:
- To review commonly used dermal fillers.
- To discuss frequent adverse reactions associated with these fillers.
- To highlight histopathologic findings for filler identification.
Main Methods:
- Review of current literature on dermal fillers.
- Analysis of adverse reactions reported for various filler types.
- Examination of characteristic histopathologic features for identification.
Main Results:
- Both rapidly and slowly biodegradable fillers can cause complications.
- Late-onset, severe reactions are more common with nonresorbable fillers.
- Histopathology provides characteristic findings for identifying injected filler agents.
Conclusions:
- Histopathologic examination is the gold standard for identifying filler agents.
- Accurate identification is essential for managing adverse reactions effectively.
- Understanding filler properties and potential complications is key for practitioners.
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