Related Experiment Video
Updated: Jun 5, 2026

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment
Published on: May 25, 2017
Tinidazole vs metronidazole for the treatment of bacterial vaginosis
Jane R Schwebke1, Renee A Desmond
1Department of Medicine, University of Alabama at Birmingham, 703 19th Street, Birmingham, AL 35294, USA. schwebke@uab.edu
Objective:
The purpose of this study was to compare the efficacy of 2 different doses of tinidazole with metronidazole for the treatment of bacterial vaginosis and to compare the side effects of the drugs.
Study Design:
Women were assigned randomly to receive metronidazole 500 mg twice daily, tinidazole 500 mg twice daily, or tinidazole 1 g twice, all for 7 days. Follow-up visits were conducted at days 14 and 28.
Results:
Five hundred ninety-three women were enrolled. There were no significant differences between the treatment arms. Overall cure rates were 76.8% at 14 days and 64.5% at 1 month. Women who admitted to engaging in sexual intercourse during the study were significantly more likely to have bacterial vaginosis at the follow-up visit. There were no significant differences in adverse events across treatment arms.
Conclusion:
There were no differences in cure rates between metronidazole and either of the tinidazole dosing regimens that were studied. In addition, there were no important differences in the side-effect profiles of metronidazole and tinidazole.
Related Concept Videos
Trichomoniasis
Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents
Automated Microbial Diagnostics
Drugs for Treatment of Diarrhea-Predominant IBS
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy
Anthelminthic Agents

