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Updated: Jun 5, 2026

Methods for Detecting Cough and Airway Inflammation in Mice

Methods for Detecting Cough and Airway Inflammation in Mice

Published on: August 2, 2024

Chronic cough and irritable larynx.

Caterina B Bucca¹, Massimiliano Bugiani, Beatrice Culla

¹Department of Clinical Pathophysiology, University of Turin, Turin, Italy. caterina.bucca@unito.it

The Journal of Allergy and Clinical Immunology

|December 21, 2010

Summary

An irritable larynx, characterized by laryngeal hyperresponsiveness (LHR), is a common cause of chronic cough (CC). Treating underlying conditions like perennial rhinitis, chronic rhinosinusitis, or GERD often resolves LHR and improves chronic cough.

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Area of Science:

Otolaryngology
Pulmonology
Gastroenterology

Background:

Chronic cough (CC) is frequently triggered by perennial rhinitis (PR), chronic rhinosinusitis (CRS), asthma, or gastroesophageal reflux disease (GERD).
Extrathoracic airway involvement is suspected due to the association of asthma with PR/CRS and potential upper airway refluxate exposure.
Previous findings suggest laryngeal hyperresponsiveness (LHR), indicative of an irritable larynx, in patients with upper airway conditions.

Purpose of the Study:

To investigate the role of laryngeal hyperresponsiveness (LHR) in patients experiencing chronic cough (CC).

Main Methods:

Assessed LHR and bronchial hyperresponsiveness (BHR) to histamine in 372 CC patients and 52 asthma-only controls.
Repeated assessments after treatment in 172 patients to evaluate the impact of addressing underlying causes.
Utilized histamine challenge to diagnose LHR and BHR.

Main Results:

PR/CRS, GERD, and unexplained cough were the primary triggers for CC in 56%, 17%, and 16% of patients, respectively.
LHR was prevalent in 76% (PR/CRS), 77% (GERD), 66% (UNEX), and 93% (asthma with CC) of patients.
Treatment resolved LHR in 63% of patients and improved it in 11%, with similar improvements noted for BHR.

Conclusions:

An irritable larynx (LHR) is a common finding in chronic cough (CC) patients.
LHR signifies upper airway involvement, stemming from rhinitis/sinusitis, GERD, or idiopathic sensory neuropathy.
Effective treatment of underlying conditions can lead to the resolution or improvement of LHR and CC.