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Sensorimotor learning in Dab1(scm) (scrambler) mutant mice.

R Lalonde1, C Strazielle

  • 1Université de Rouen, Faculté des Sciences, Dépt. Psychologie, 76821 Mont-Saint-Aignan, France. robert.lalonde@univ-rouen.fr

Behavioural Brain Research
|December 21, 2010
PubMed
Summary

Mice with cerebellar degeneration showed severe motor deficits on a rotorod test. However, these same mice improved on a grid-climbing test, indicating residual learning capacity for balance.

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Neurobehavioral performances and brain regional metabolism in Dab1(scm) (scrambler) mutant mice.

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Area of Science:

  • Neuroscience
  • Developmental Neuroscience
  • Genetics

Background:

  • The Dab1 gene plays a crucial role in neuronal migration during brain development.
  • Mutations in Dab1 can lead to severe cerebellar and neocortical abnormalities, including cell ectopias.
  • Understanding the functional consequences of these abnormalities is vital for studying brain development and function.

Purpose of the Study:

  • To assess motor coordination and learning abilities in homozygous Dab1(scm) mouse mutants with significant cerebellar degeneration.
  • To compare the performance of these mutants with non-ataxic controls on established motor coordination tasks.
  • To evaluate the utility of the grid-climbing test in assessing residual sensorimotor functions in mice with severe cerebellar damage.

Main Methods:

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  • Homozygous Dab1(scm) mouse mutants and non-ataxic controls were subjected to two motor coordination tests: the rotorod and grid climbing.
  • Performance was evaluated based on the ability to maintain balance and learn over repeated trials.
  • Constant speed rotorod and vertical grid climbing tests were employed to assess different aspects of motor control.

    • Main Results:

    • Dab1(scm) mutants failed to reach criterion on the constant speed rotorod test, even at low speeds, highlighting significant motor impairment.
    • In contrast, Dab1(scm) mutants demonstrated improvement in performance on the vertical grid climbing test over time.
    • This suggests a preserved capacity for sensorimotor learning despite extensive cerebellar degeneration.

    Conclusions:

    • Massive cerebellar degeneration in Dab1(scm) mutants severely impacts performance on tasks requiring sustained equilibrium.
    • Sensorimotor learning for equilibrium is still possible in these mutants, as evidenced by their improvement on the grid-climbing task.
    • The grid-climbing test is a valuable tool for assessing residual motor functions in mouse models with profound cerebellar damage.