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Nuclear magnetic resonance spectra and molecular structure of mesna
1Institut für Anorganische Chemie und Strukturchemie, Heinrich-Heine-Universität Düsseldorf, Fed. Rep. of Germany.
Arzneimittel-Forschung
|May 1, 1990
Abstract:
Mesna (2-mercapto-ethane sulfonic acid sodium salt) is used as a reliably acting uroprotector in cancer chemotherapy with oxazaphosphorine cytostatics. 1H-, 13C[1H]- and C,H-COSY-NMR-spectra are analyzed. In solution state mesna exists predominantly in a trans-rotameric form. These findings are supported by hypothetical gas-phase-structures of mesna, simulated via the program system MOPAC.