Related Experiment Video
Updated: Jun 5, 2026
09:54
Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death
Published on: August 15, 2022
ABO-incompatible living-donor lobar lung transplantation
Tsuyoshi Shoji1, Toru Bando, Takuji Fujinaga
1Department of Thoracic Surgery, Kyoto University, 54 Shogoin-Kawahara-cho, Kyoto, Japan. tshoji@kuhp.kyoto-u.ac.jp
Summary
This study reports the first successful ABO-incompatible living-donor lobar lung transplant in a child with bronchiolitis obliterans. The transplant utilized type B and AB donor lungs after the patient
Area of Science:
- Pediatric Hematology-Oncology
- Transplantation Immunology
- Thoracic Surgery
Background:
- A 10-year-old boy developed bronchiolitis obliterans (BO) following bone marrow transplantation (BMT) for acute myeloid leukemia (AML).
- The patient's blood type changed from AB to O post-BMT, resulting in a lack of anti-A/B antibodies.
Observation:
- The patient required a lung transplant due to severe BO.
- Conventional ABO-compatible living-donor lung transplantation was not feasible.
Findings:
- The patient successfully received lobar lung grafts from ABO-incompatible living donors (type B and type AB).
- This represents the first documented case of ABO-incompatible living-donor lobar lung transplantation.
Implications:
- This pioneering procedure demonstrates the potential of ABO-incompatible living-donor lung transplantation in select pediatric cases.
- Offers a potential alternative for patients with limited donor options after BMT for hematologic malignancies.
