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lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...

Chromatin Structure Regulates pre-mRNA Processing

Chromatin Structure Regulates pre-mRNA Processing

In eukaryotic cells, nascent mRNA transcripts need to undergo many post-transcriptional modifications to reach the cell cytoplasm and translate into functional proteins. For a long time, transcription and pre-mRNA processing were considered two independent events that occur sequentially in the cell. However, it has now been well established that transcription and pre-mRNA processing are two simultaneous processes that are precisely regulated inside the cell.
The chromatin structure, especially...

Types of RNA

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...

Types of RNA

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...

Inheritance of Chromatin Structures

Inheritance of Chromatin Structures

Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying DNA...

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Related Experiment Video

Updated: Jun 5, 2026

Chromatin Isolation by RNA Purification (ChIRP)

Chromatin Isolation by RNA Purification (ChIRP)

Published on: March 25, 2012

Long non-coding RNAs and chromatin regulation.

Filomena De Lucia¹, Caroline Dean

¹Department of Cell & Developmental Biology, John Innes Centre, Norwich, UK. Menita.De-Lucia@bbsrc.ac.uk

Current Opinion in Plant Biology

|December 21, 2010

Summary

This summary is machine-generated.

Long non-coding RNAs (ncRNAs) play regulatory roles in plants, influencing transcription and phenotypic plasticity. These findings expand our understanding of genome regulation beyond protein-coding genes.

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Chromatin Isolation by RNA Purification (ChIRP)

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RNA-Associated Chromatin DNA-DNA Interaction Method

RNA-Associated Chromatin DNA-DNA Interaction Method

Published on: April 30, 2026

Area of Science:

Molecular Biology
Genomics
Plant Science

Background:

Recent advances in sequencing reveal extensive genome transcription in eukaryotes, producing abundant non-coding RNA (ncRNA).
The functional significance of ncRNA remains a key area of research, with known regulatory mechanisms including transcriptional effects and chromatin modification.
While extensively studied in yeasts and mammals, ncRNA functions are increasingly being identified in plants.

Purpose of the Study:

To investigate the role of long non-coding RNAs (lncRNAs) in RNA-mediated transcriptional silencing in plants.
To explore the involvement of lncRNAs in plant phenotypic plasticity and responses to environmental cues.

Main Methods:

Utilizing microarray analysis and next-generation sequencing technologies.
Analyzing whole-genome expression data to identify ncRNA involvement in plant responses.
Reviewing existing literature on RNA-mediated silencing mechanisms in various organisms.

Main Results:

Evidence suggests that lncRNAs, in addition to small interfering RNAs (siRNAs), are involved in RNA-mediated transcriptional silencing in plants.
Whole-genome analysis indicates that external stimuli significantly impact lncRNA expression, suggesting a role in phenotypic plasticity.

Conclusions:

Long non-coding RNAs are emerging as critical regulators of gene expression and phenotypic adaptation in plants.
Further research into lncRNA mechanisms will be crucial for understanding plant development and environmental responses.