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The vestibular evoked-potential profile of Ménière's disease

Rachael L Taylor1, Ayanthi A Wijewardene, William P R Gibson

  • 1Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, Central Clinical School, University of Sydney, NSW, Australia.

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
|December 21, 2010
PubMed
Abstract

Insights

Ménière

Area of Science:

  • Neuroscience
  • Otolaryngology
  • Audiology

Background:

  • Ménière's disease (MD) is a complex inner ear disorder.
  • Vestibular evoked myogenic potentials (VEMPs) assess otolith function.
  • Ocular VEMPs (oVEMPs) and cervical VEMPs (cVEMPs) provide complementary information.

Purpose of the Study:

  • To characterize the oVEMP and cVEMP profile in Ménière's disease.
  • To investigate responses to air-conducted (AC) sound and bone-conducted vibration (BCV).
  • To differentiate MD from other peripheral vestibulopathies.

Main Methods:

  • Recorded oVEMPs and cVEMPs in 77 MD patients and 35 controls.
  • Utilized AC clicks and BCV stimuli (mini-shaker, tendon-hammer).
  • Analyzed Reflex Asymmetry Ratios (AR) and correlations with hearing loss.

Main Results:

  • 50% of unilateral MD patients showed abnormal oVEMPs and 40% abnormal cVEMPs with AC clicks.
  • Abnormalities were more prevalent with AC than BCV stimuli.
  • AC VEMP abnormalities correlated significantly with hearing loss and caloric asymmetry.

Conclusions:

  • Abnormalities in oVEMP and cVEMP responses to AC sound are characteristic of MD.
  • This pattern suggests saccular involvement in Ménière's disease.
  • VEMP testing may help distinguish MD from other peripheral vestibulopathies.

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