Role of Ca(V)2.1-mediated NMDA receptor signaling in the nucleus accumbens in spatial short-term memory
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Updated: Jun 5, 2026

Aversive Associative Learning and Memory Formation by Pairing Two Chemicals in Caenorhabditis elegans
Published on: June 23, 2022
Eiki Takahashi1, Kimie Niimi, Chitoshi Itakura
1Research Resources Center, RIKEN Brain Science Institute, Hirosawa 2-1, Wako, Saitama, 351-0198, Japan. etakahashi@brain.riken.jp
Abstract:
Heterozygous rolling Nagoya (rol/+) mice with a Ca(V)2.1α₁ mutation show normal Y-maze behavior. Intra-accumbens injection of N-methyl-d-aspartate (NMDA; 0-2.0 μg/side) induced similar spontaneous alternations in wild-type and rol/+ mice; injections of NMDA receptor antagonist MK-801 (0.5 μg/side) or Ca(V)2.1 inhibitor levetiracetam (0.1 μg/side) did not affect controls but decreased spatial cognition in rol/+ mice, suggesting that Ca(V)2.1-mediated NMDA receptor signaling in the nucleus accumbens is involved in short-term spatial learning.
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