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Published on: April 13, 2021

Incidence and risk factors for pulmonary mycosis in kidney transplantation

G Chen1, Z Zhang, J Gu

  • 1Organ Transplant Center, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.

Transplantation Proceedings
|December 21, 2010
PubMed
Abstract

Insights

Pulmonary mycosis is a serious risk after kidney transplants. Potent immunosuppression and factors like older age, retransplantation, and leukopenia increase this risk, especially with multiple risk factors present.

Area of Science:

  • Nephrology
  • Transplantation Immunology
  • Infectious Diseases

Background:

  • Pulmonary mycosis is a severe complication post-kidney transplant, linked to high mortality.
  • The incidence and risk factors for post-transplant pulmonary mycosis require further investigation.

Purpose of the Study:

  • To identify independent risk factors for pulmonary mycosis in kidney transplant recipients.
  • To analyze the association between immunosuppressive regimens and pulmonary mycosis development.

Main Methods:

  • Retrospective review of 2573 kidney transplant recipients.
  • Comparison of patients with and without pulmonary mycosis.
  • Analysis of baseline characteristics, complications, immunosuppression, and antibiotic use.

Main Results:

  • Pulmonary mycosis incidence was 2.1% in kidney recipients.
  • Independent risk factors identified include older age, retransplantation, ATG induction, FK506/MMF use, broad-spectrum antibiotics, leukopenia, and delayed incisional healing.
  • Potent immunosuppressive regimens were associated with increased pulmonary mycosis rates.

Conclusions:

  • Stronger immunosuppressive strategies may elevate pulmonary mycosis risk.
  • Patients with five or more identified risk factors face a significantly higher risk of developing pulmonary mycosis.

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