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Updated: Jun 5, 2026
08:58
Murine Kidney Transplant Technique
Published on: October 20, 2015
Postoperative bleeding after AB0-incompatible living donor kidney transplantation
F C Renner1, B Czekalinska, B Kemkes-Matthes
1Department of Internal Medicine, Nephrology and Renal Transplantation, University of Giessen, Germany.
Transplantation Proceedings
|December 21, 2010
Summary
Postoperative bleeding after ABO-incompatible kidney transplants was linked to high heparin doses. Reducing heparin significantly lowered bleeding complications without affecting graft function, improving patient outcomes.
Area of Science:
- Nephrology
- Transplantation Immunology
- Vascular Surgery
Background:
- ABO-incompatible (ABOi) living kidney transplantation is crucial for increasing organ availability.
- A previous protocol involved perfusing donor kidneys with a heparin-containing solution.
Purpose of the Study:
- To investigate the cause of postoperative hemorrhage in ABOi kidney transplant recipients.
- To determine the impact of heparin dosage on post-transplant bleeding.
Main Methods:
- Prospective coagulation studies (PTT, thrombin time, etc.) were performed before and after graft anastomosis in 14 ABOi kidney transplant recipients.
- Coagulation parameters were analyzed in relation to heparin administration and bleeding events.
Main Results:
- Elevated partial thromboplastin time (PTT) values post-anastomosis were identified as a heparin effect in patients experiencing bleeding.
- Reducing the heparin dose from 10,000-20,000 IU to 4000 IU significantly decreased PTT values and eliminated further bleeding complications.
- Graft function, assessed by serum creatinine, remained unaffected by the reduced heparin dosage.
Conclusions:
- Postoperative hemorrhage in ABOi kidney transplantation is associated with the amount of heparin used during perfusion.
- Lowering heparin dosage is a safe and effective strategy to prevent bleeding complications.
- Antifibrinolytic agents are not indicated in ABOi kidney transplantation due to the absence of hyperfibrinolysis.
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