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Updated: Jun 5, 2026
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Published on: October 27, 2014
The impact of intravitreal bevacizumab therapy on choroidal melanoma
Breno R Lima1, Lynn R Schoenfield, Arun D Singh
1Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
Purpose:
To describe the clinical course and ancillary findings of 3 patients with choroidal melanoma who inadvertently received multiple intravitreal injections of bevacizumab for a presumed diagnosis of choroidal neovascular membrane.
Design:
Observational case series.
Methods:
Three patients with choroidal melanomas who received a series of monthly intravitreal injections of bevacizumab for presumed choroidal neovascularization were evaluated. Clinical, ultrasonographic, and angiographic findings are presented. Histopathologic features are correlated with clinical features in 2 patients who underwent enucleation.
Results:
Lack of benefit in halting tumor progression was observed in all 3 cases. In 2 cases treated with enucleation, there was evidence of bevacizumab-induced gliotic/fibrotic retinal changes.
Conclusions:
We present 3 cases of choroidal melanomas that showed progression while patients received multiple intravitreal injections of bevacizumab. The use of the drug led to the formation of a gliotic/fibrotic membrane that resulted in masking of the underlying tumor and consequently delayed the correct diagnosis.
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