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Updated: Jun 5, 2026
07:54
Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
Balanced propofol sedation for therapeutic GI endoscopic procedures: a prospective, randomized study
Chang Kyun Lee1, Suck-Ho Lee, Il-Kwun Chung
1Department of Internal Medicine, Kyung Hee University School of Medicine, Seoul, Korea.
Gastrointestinal Endoscopy
|December 21, 2010
Summary
Balanced propofol sedation (BPS) offers improved provider satisfaction and patient cooperation during endoscopic procedures compared to conventional methods. Safety profiles remain similar, making BPS a viable alternative for therapeutic endoscopy.
Area of Science:
- Gastroenterology
- Anesthesiology
- Clinical Medicine
Background:
- Limited controlled studies exist on balanced propofol sedation (BPS) for therapeutic endoscopy.
- BPS involves propofol combined with midazolam and meperidine.
Purpose of the Study:
- To compare the safety and efficacy of BPS versus conventional sedation (midazolam and meperidine).
- To evaluate outcomes in patients undergoing therapeutic endoscopic procedures.
Main Methods:
- Prospective, randomized, single-blinded study at a tertiary-care referral center.
- 222 patients undergoing therapeutic EGD or ERCP received either conventional sedation or BPS.
- Outcomes included sedation-related cardiopulmonary complications, procedure interruptions, and provider/patient satisfaction.
Main Results:
- No significant differences in cardiopulmonary complications or procedure interruptions between BPS and conventional sedation groups.
- BPS demonstrated significantly higher health care provider satisfaction (endoscopists and nurses) and better patient cooperation.
- No patients required assisted ventilation or premature procedure termination.
Conclusions:
- Balanced propofol sedation (BPS) is comparable to conventional sedation in terms of safety for therapeutic endoscopic procedures.
- BPS enhances provider satisfaction and patient cooperation without increasing adverse events.
- BPS represents a beneficial alternative for sedation in therapeutic endoscopy.
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