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Related Experiment Video

Updated: Jun 5, 2026

E-Patient Counseling Trial (E-PACO): Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy

E-Patient Counseling Trial (E-PACO): Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy

Published on: August 1, 2019

Computer-assisted personalized sedation for upper endoscopy and colonoscopy: a comparative, multicenter randomized

Daniel J Pambianco¹, John J Vargo, Ronald E Pruitt

¹Charlottesville Medical Research and Charlottesville Gastroenterology Associates, 325 Winding River Lane, Suite 102, Charlottesville, VA 22911, USA.

Gastrointestinal Endoscopy

|December 21, 2010

Summary

This summary is machine-generated.

The investigational SEDASYS System demonstrated improved safety and effectiveness for propofol sedation during endoscopic procedures compared to standard care. Patients and clinicians reported higher satisfaction with the SEDASYS System, with faster recovery times and fewer adverse events.

Related Experiment Videos

Last Updated: Jun 5, 2026

E-Patient Counseling Trial (E-PACO): Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy

E-Patient Counseling Trial (E-PACO): Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy

Published on: August 1, 2019

Area of Science:

Gastroenterology
Anesthesiology
Medical Device Technology

Background:

The SEDASYS System is an investigational computer-assisted system for personalized propofol sedation during endoscopic procedures.
It integrates propofol delivery with patient monitoring to assist endoscopist/nurse teams.

Purpose of the Study:

To compare the safety and effectiveness of the SEDASYS System against the current standard of care for sedation in routine endoscopic procedures.

Main Methods:

A nonblinded, multicenter, randomized comparative study was conducted across various US centers.
One thousand patients (ASA physical status I-III) undergoing routine colonoscopy or EGD were randomized.
Interventions included sedation with the SEDASYS System (SED) versus current standard of care (CSC; benzodiazepine/opioid combination).

Main Results:

The SEDASYS System group (SED) showed a significantly lower area under the curve of oxygen desaturation (23.6 s·%) compared to the current standard of care (CSC) group (88.0 s·%; P = .028).
Patients in the SED group reported significantly higher satisfaction (P = .007), and clinicians reported greater satisfaction (P < .001).
SED patients experienced faster recovery (P < .001) with a lower incidence of adverse events (5.8% vs. 8.7%).

Conclusions:

The SEDASYS System offers a safe and effective method for administering propofol for minimal to moderate sedation during routine colonoscopy and EGD.
It provides endoscopist/nurse teams with an on-label option for enhanced procedural sedation.