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[Diabetes, malnutrition and growth retardation]
J M Ketelslegers1, M Maes, D Maiter
1Unité de Diabétologie et Nutrition, Faculté de Médecine, l'Université catholique de Louvain-en-Woluwe.
Bulletin Et Memoires De L'Academie Royale De Medecine De Belgique
|January 1, 1990
Abstract:
We investigated the cellular mechanisms responsible for growth hormone (GH) resistance in diabetes and malnutrition in the rat. In insulin-dependent diabetes, a post-receptor defect participates in GH resistance. During fasting, there is a loss of liver GH binding sites. Dietary protein restriction causes a post-receptor defect. This defect can be attributed to the combined effects of decreased liver IGF-I mRNA content and impaired message translation.