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Updated: Jun 5, 2026

Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats

Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats

Published on: December 13, 2019

Arterial wave reflection and subclinical left ventricular systolic dysfunction.

Cesare Russo¹, Zhezhen Jin, Yasuyoshi Takei

¹Department of Medicine, Columbia University, College of Physicians & Surgeons, 630 West 168th Street, New York, NY 10032, USA.

Journal of Hypertension

|December 21, 2010

Summary

Increased arterial wave reflection is linked to reduced subclinical left-ventricular (LV) systolic function in individuals without heart failure. This association was observed using tissue Doppler imaging (TDI) and aortic augmentation index (AIx).

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Last Updated: Jun 5, 2026

Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats

Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats

Published on: December 13, 2019

Area of Science:

Cardiovascular Physiology
Arterial Hemodynamics
Echocardiography

Background:

Increased arterial wave reflection is a known cardiovascular event predictor.
Arterial wave reflection's role in heart failure pathophysiology is hypothesized.
The association between wave reflection and left-ventricular (LV) systolic function in individuals without heart failure is unclear.

Purpose of the Study:

To investigate the relationship between arterial wave reflection and LV systolic function in individuals without heart failure.
To determine if increased wave reflection is inversely associated with LV systolic function in a healthy cohort.

Main Methods:

301 participants from the Cardiovascular Abnormalities and Brain Lesions (CABL) study were analyzed.
Arterial wave reflection was assessed using aortic augmentation index (AIx) and wasted energy index (WEi).
LV systolic function was measured by LV ejection fraction (LVEF) and tissue Doppler imaging (TDI) parameters like mitral annulus peak systolic velocity (Sm).

Main Results:

LV systolic function assessed by TDI was lower with increasing wave reflection.
Left-ventricular ejection fraction (LVEF) did not show a significant association with wave reflection.
Multivariate analysis revealed significant inverse correlations between TDI parameters of LV longitudinal systolic function and AIx/WEi.

Conclusions:

Increased arterial wave reflection is associated with subclinical reduction in LV systolic function in individuals without heart failure and normal LVEF.
Novel tissue Doppler imaging (TDI) techniques revealed this association.
Further research is needed to explore the prognostic implications of this relationship.