Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Fractures: Bone Repair01:27

Fractures: Bone Repair

Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Imperfections in Crystal Structure: Non-Stoichiometric Defects01:29

Imperfections in Crystal Structure: Non-Stoichiometric Defects

Non-stoichiometric defects refer to a type of defect in the crystal structure of a compound where the ratio of its constituent elements deviates from the ideal stoichiometric ratio. There are two main types of non-stoichiometric defects: metal excess defects and metal deficiency defects.Metal excess defects occur when there is a slight surplus of metal ions than what is required by the stoichiometric ratio of the compound. For example, heating a sodium chloride crystal in sodium vapor results...
Mismatch Repair01:20

Mismatch Repair

Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
Base Excision Repair01:54

Base Excision Repair

One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
The first step of...
Fixing Double-strand Breaks02:04

Fixing Double-strand Breaks

The double-stranded structure of DNA has two major advantages. First, it serves as a safe repository of genetic information where one strand serves as the back-up in case the other strand is damaged. Second, the double-helical structure can be wrapped around proteins called histones to form nucleosomes, which can then be tightly wound to form chromosomes. This way, DNA chains up to 2 inches long can be contained within microscopic structures in a cell. A double-stranded break not only damages...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Interventions for managing taste disturbances.

The Cochrane database of systematic reviews·2017
Same author

Spontaneous Gingival Bleeding A Surprising and Sinister Etiology: A Case Report.

The New York state dental journal·2016
Same author

Beneficial effects seen with most desensitising toothpastes.

Evidence-based dentistry·2016
Same author

Interventions for the management of taste disturbances.

The Cochrane database of systematic reviews·2014
Same author

Dental management of a liver transplant patient--case report.

The Journal of the Michigan Dental Association·2014
Same author

Dental management of liver transplant patient.

The New York state dental journal·2013
Same journal

Selective caries removal or pulpotomy: which approach is better for 'deep' carious lesions?

Evidence-based dentistry·2026
Same journal

Application of deep machine learning in dental education: a systematic review of effectiveness in dental students' teaching learning outcomes.

Evidence-based dentistry·2026
Same journal

Can systemic resveratrol improve periodontal treatment outcomes in smokers?

Evidence-based dentistry·2026
Same journal

Is tooth loss associated with subsequent cognitive decline and dementia in ageing populations?

Evidence-based dentistry·2026
Same journal

Do sleep bruxism patients experience higher complication or failure rates with monolithic lithium disilicate or zirconia molar crowns?

Evidence-based dentistry·2026
Same journal

"Spin" in randomized controlled trials of digital implant surgery: a meta-epidemiologic study.

Evidence-based dentistry·2026
See all related articles

Related Experiment Video

Updated: Jun 5, 2026

Detection and Removal of Tooth-Colored Composite Resin Using the Fluorescence-Aided Identification Technique
05:42

Detection and Removal of Tooth-Colored Composite Resin Using the Fluorescence-Aided Identification Technique

Published on: July 27, 2022

Defective amalgams - repair or replace?

David Levenson1, Analia V Keenan

  • 1NYU College of Dentistry, PEARL Network Practitioners, New York, USA.

Evidence-Based Dentistry
|December 21, 2010
PubMed
Summary
This summary is machine-generated.

No randomized controlled trials were found comparing amalgam restoration repair versus replacement. Further research is needed to address patient experiences and costs.

More Related Videos

Quasistatic Mechanical Testing for Computer-Aided Design and Manufacturing Occlusal Veneers Cemented to Milled Dentin Analog Material
07:42

Quasistatic Mechanical Testing for Computer-Aided Design and Manufacturing Occlusal Veneers Cemented to Milled Dentin Analog Material

Published on: December 20, 2024

Development of Amelogenin-chitosan Hydrogel for In Vitro Enamel Regrowth with a Dense Interface
08:26

Development of Amelogenin-chitosan Hydrogel for In Vitro Enamel Regrowth with a Dense Interface

Published on: July 10, 2014

Related Experiment Videos

Last Updated: Jun 5, 2026

Detection and Removal of Tooth-Colored Composite Resin Using the Fluorescence-Aided Identification Technique
05:42

Detection and Removal of Tooth-Colored Composite Resin Using the Fluorescence-Aided Identification Technique

Published on: July 27, 2022

Quasistatic Mechanical Testing for Computer-Aided Design and Manufacturing Occlusal Veneers Cemented to Milled Dentin Analog Material
07:42

Quasistatic Mechanical Testing for Computer-Aided Design and Manufacturing Occlusal Veneers Cemented to Milled Dentin Analog Material

Published on: December 20, 2024

Development of Amelogenin-chitosan Hydrogel for In Vitro Enamel Regrowth with a Dense Interface
08:26

Development of Amelogenin-chitosan Hydrogel for In Vitro Enamel Regrowth with a Dense Interface

Published on: July 10, 2014

Area of Science:

  • Dental materials science
  • Evidence-based dentistry
  • Clinical trial methodology

Background:

  • Systematic review of randomized controlled trials (RCTs) on amalgam restoration repair versus replacement.
  • Comprehensive search of multiple databases including Cochrane, Medline, Embase, and Web of Science.

Discussion:

  • Identified 145 potentially eligible studies, but only three were analyzed further.
  • None of the selected studies met the inclusion criteria for this review.
  • Significant lack of high-quality RCTs in this specific area of restorative dentistry.

Key Insights:

  • No published randomized controlled clinical trials (RCTs) were found relevant to the review question.
  • Current evidence base is insufficient to guide clinical decisions on amalgam repair versus replacement.
  • There is a critical need for methodologically sound RCTs.

Outlook:

  • Future research should adhere to Consolidated Standards of Reporting Trials (CONSORT) guidelines.
  • Qualitative research is recommended to explore patient perspectives on pain, anxiety, time, and costs associated with repair versus replacement.
  • Further investigation into the long-term efficacy and patient-centered outcomes is warranted.