Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ventilatory responses to inspiratory threshold loading in humans.

J Yanos1, A Banner, R Stanko

  • 1Montefiore Hospital, Pulmonary Unit, University of Pittsburgh, Pennsylvania 15213.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|June 1, 1990
PubMed
Summary

External mechanical loading on breathing typically maintains ventilation. This study found sustained threshold loading causes hyperventilation and increased tidal volumes in healthy individuals, with effects persisting after load removal.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Consequences of patient denial at first exemption request for cardiac transplantation.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation·2025
Same author

Why is translating research into policy so hard? How theory can help public health researchers achieve impact?

Public health·2019
Same author

Androstadienone, a putative chemosignal of dominance, increases gaze avoidance among men with high social anxiety.

Psychoneuroendocrinology·2018
Same author

The spectrum of skin diseases occurring in a multiethnic population in north-west London, U.K.: findings from a cross-sectional descriptive study.

The British journal of dermatology·2016
Same author

Ecosystem mapping methods for British Columbia.

Environmental monitoring and assessment·2013
Same author

The development of an ecological classification data management and analysis system for British Columbia.

Environmental monitoring and assessment·2013

Area of Science:

  • Respiratory Physiology
  • Mechanics of Breathing
  • Neuroscience of Respiration

Background:

  • Alveolar ventilation is usually maintained despite external mechanical loading.
  • The mechanisms for this compensation, including muscular, neural, and chemoreceptor factors, are not fully understood.
  • Previous studies suggest threshold loading might induce hyperventilation.

Purpose of the Study:

  • To investigate the respiratory effects of sustained threshold loading in healthy subjects.
  • To determine if threshold loading leads to hyperventilation and changes in respiratory parameters.
  • To examine the persistence of respiratory responses after load removal.

Main Methods:

  • Subjects were exposed to sustained threshold loading.
  • Respiratory parameters including mouth pressure (P100), tidal volume, duty cycle, and respiratory rate were measured.

Related Experiment Videos

  • Responses were assessed during loading and after load removal.

    • Main Results:

    • Sustained threshold loading resulted in hyperventilation, elevated P100, and increased tidal volumes.
    • Respiratory rate and duty cycle showed minimal changes.
    • The increased respiratory motor output persisted for 30-60 seconds post-loading.
    • At very high loads, hyperventilation was abolished despite increased P100.

    Conclusions:

    • Threshold loading increases respiratory motor output and causes hyperventilation in healthy individuals.
    • This response differs from that seen with resistive or elastic loads.
    • Mechanical limitations may explain the failure to hyperventilate at very high threshold loads.