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Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
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Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
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Nephrons

The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma happens...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

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Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

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Related Experiment Video

Updated: Jun 5, 2026

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

Klotho and kidney disease.

Ming-Chang Hu1, Makoto Kuro-o, Orson W Moe

  • 1Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 7390-8855, USA. Ming-chang.hu@utsouthwestern.edu

Journal of Nephrology
|December 21, 2010
PubMed
Summary
This summary is machine-generated.

Klotho protein deficiency worsens kidney disease and calcification. Klotho repletion may preserve kidney function and prevent vascular calcification, showing therapeutic potential.

Related Experiment Videos

Last Updated: Jun 5, 2026

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

Area of Science:

  • Nephrology
  • Endocrinology
  • Molecular Biology

Background:

  • Klotho protein exists in membrane-bound and soluble forms, performing diverse biological functions.
  • Soluble Klotho acts as an endocrine hormone and directly inhibits renal phosphate excretion.
  • Klotho deficiency is characteristic of acute kidney injury (AKI) and chronic kidney disease (CKD).

Purpose of the Study:

  • To elucidate the multifaceted roles of Klotho in renal physiology and pathology.
  • To investigate Klotho's function beyond its role as a fibroblast growth factor-23 (FGF23) coreceptor.
  • To explore Klotho's potential as a biomarker and therapeutic target in kidney diseases.

Main Methods:

  • Review of Klotho's known functions in renal tubules and systemic circulation.
  • Analysis of Klotho's impact on glomerular filtration rate (GFR) in AKI and CKD models.
  • Examination of Klotho's mechanisms in preventing soft tissue and vascular calcification.

Main Results:

  • Klotho deficiency exacerbates kidney function decline in AKI and CKD.
  • Klotho repletion or excess preserves glomerular filtration rate.
  • Klotho mitigates soft tissue and vascular calcification through phosphaturia, renal function preservation, and direct vascular effects.

Conclusions:

  • Klotho is a critical factor in renal disease pathogenesis and progression.
  • Klotho serves as a sensitive biomarker for impaired renal function.
  • Klotho holds significant potential for diagnostic, prognostic, and therapeutic applications in kidney disease.