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A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

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Ageing and changes in phosphate transport: clinical implications.

Massimo Cirillo¹, Giancarlo Bilancio, Fabiana Marcarelli

¹Centre for Interdepartmental Clinical Research, Unit of Nephrology, Second University of Naples, Naples, Italy. massimo.cirillo@unina2.it

Journal of Nephrology

|December 21, 2010

Summary

Serum phosphorus levels naturally decline with age, impacting kidney dysfunction complications. This age-related decline suggests hyperphosphatemia prevalence may be higher in younger adults with kidney issues.

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Area of Science:

Nephrology
Gerontology
Endocrinology

Background:

Hyperphosphatemia is a significant complication of kidney dysfunction.
Current guidelines link hyperphosphatemia to glomerular filtration rates below 60 ml/min.
The relationship between aging, serum phosphorus, and kidney dysfunction requires further investigation.

Purpose of the Study:

To explore the relationship between age and serum phosphorus levels.
To investigate how this relationship influences hyperphosphatemia in kidney dysfunction.
To re-evaluate the association between kidney function and serum phosphorus, considering age.

Main Methods:

Analysis of epidemiologic studies on age-related changes in serum phosphorus.
Examination of data on maximal phosphorus reabsorption in the renal proximal tubule (TmP/GFR).
Review of clinical studies correlating age, kidney dysfunction, and hyperphosphatemia prevalence.

Main Results:

Serum phosphorus decreases with age in both pediatric and adult populations.
Age-associated differences in serum phosphorus are linked to TmP/GFR, influenced by growth hormone and estrogen.
Hyperphosphatemia secondary to kidney dysfunction is approximately four times more prevalent in adults younger than 65 compared to those older than 65.

Conclusions:

The natural decline in serum phosphorus with age may confound the assessment of kidney dysfunction.
The prevalence of hyperphosphatemia in kidney dysfunction might be underestimated in the elderly.
Age should be considered a crucial factor when evaluating kidney function and serum phosphorus levels.