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Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Allergic Reactions02:06

Allergic Reactions

Overview
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...

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Structural Basis of IgE Binding to α- and γ-Gliadins: Contribution of Disulfide Bonds and Repetitive and Nonrepetitive Domains.

Journal of agricultural and food chemistry·2015
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[Genesis of food allergy in infancy].

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Molecular and immunological characterization of wheat Serpin (Tri a 33).

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Mammalian meat-induced anaphylaxis: clinical relevance of anti-galactose-alpha-1,3-galactose IgE confirmed by means of skin tests to cetuximab.

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[Drugs as risk factors of food anaphylaxis in adults: a case-control study].

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Related Experiment Video

Updated: Jun 5, 2026

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
03:23

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis

Published on: May 10, 2024

[Eosinophilic inflammation in allergic diseases].

Denise-Anne Moneret-Vautrin1

  • 1Académie nationale de médecine. pramoneret@hotmail.com

Bulletin De L'Academie Nationale De Medecine
|December 22, 2010
PubMed
Summary

Tissular eosinophilia is not exclusive to atopy. Complex mechanisms involving Th1 activation and epithelial cell signaling drive eosinophilic inflammation in various allergic and non-allergic diseases.

Area of Science:

  • Immunology
  • Allergy Research
  • Pathophysiology

Context:

  • Tissular eosinophilia is a hallmark of IgE-dependent allergic diseases, traditionally linked to Th2 lymphocyte activation.
  • Comparisons between allergic and non-atopic 'mirror' diseases reveal more complex pathophysiological mechanisms.
  • This review examines allergic asthma alongside intrinsic asthma, Churg-Strauss syndrome, nasal polyposis, vernal conjunctivitis, eosinophilic esophagitis, DRESS, Ofuji disease, and eosinophilic cystitis.

Purpose:

  • To explore the intricate links between allergic diseases and their non-atopic counterparts.
  • To challenge the classical concept that Th2 activation and tissular eosinophilia are exclusive hallmarks of atopy.
  • To investigate alternative mechanisms of eosinophil recruitment and activation in diverse inflammatory conditions.

More Related Videos

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation
08:44

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation

Published on: May 30, 2020

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
10:39

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

Published on: April 16, 2019

Related Experiment Videos

Last Updated: Jun 5, 2026

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
03:23

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis

Published on: May 10, 2024

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation
08:44

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation

Published on: May 30, 2020

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
10:39

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

Published on: April 16, 2019

Summary:

  • Recent studies indicate Th2 activation with tissular eosinophilia is not solely indicative of atopy.
  • Allergic inflammation can be driven by Th1 activation, particularly when coupled with viral infections, as seen in DRESS syndrome.
  • An alternative concept highlights the epithelium's predominant role in eosinophil attraction, exemplified by eosinophilic esophagitis.

Impact:

  • Findings suggest Th2 activation is not the sole driver of eosinophilic inflammation in allergic diseases.
  • The role of Th1 activation and epithelial signaling in eosinophil recruitment offers new perspectives on disease mechanisms.
  • Identifying epithelial eotaxin 3 expression as a therapeutic target could lead to novel treatments for eosinophilic disorders.