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Collection of Post-mating Semen from the Female Reproductive Tract and Measurement of Semen Liquefaction in Mice
Published on: November 18, 2017
[Apigenin affects semen parameters in male mice]
Xiao-rong Shi1, Shu-yu Liu, Ya Chen
1Maternal and Child Health Service of Chengguan District, Lanzhou, Gansu 730030, China.
Zhonghua Nan Ke Xue = National Journal of Andrology
|December 22, 2010
Summary
High-dose apigenin significantly reduced sperm motility and velocity in male mice after 14 days. Further research is needed to understand apigenin
Area of Science:
- Reproductive biology
- Toxicology
- Pharmacology
Context:
- Apigenin, a natural flavonoid, is found in various plants.
- Its effects on male reproductive health require detailed investigation.
- Understanding potential impacts of dietary compounds on fertility is crucial.
Purpose:
- To investigate the impact of apigenin on sperm parameters in male mice.
- To determine dose-dependent effects and duration of exposure.
Summary:
- Male mice received varying doses of apigenin for 7 or 14 days.
- After 7 days, no significant changes in sperm parameters were observed.
- After 14 days, high-dose apigenin significantly decreased sperm motility, velocity (VAP, VSL), and increased beat cross frequency (BCF).
Impact:
- Apigenin, at high doses and prolonged exposure, may negatively affect male reproductive parameters.
- These findings highlight the need for careful consideration of apigenin dosage in potential therapeutic or dietary contexts.
- Further studies are warranted to elucidate the mechanisms underlying these effects and their relevance to human health.
