Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Aerosols for systemic treatment.

D Köhler1

  • 1Fachkrankenhaus Kloster Grafschaft, Schmallenberg, Federal Republic of Germany.

Lung
|January 1, 1990
PubMed
Summary

Inhaled drug delivery via aerosols offers an alternative to injections for polypeptides, overcoming challenges like dose accuracy and systemic absorption. Recent advancements show promise for efficient and safe aerosolized systemic drug treatments.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prediction of abdominal CT body composition parameters by thoracic measurements as a new approach to detect sarcopenia in a COVID-19 cohort.

Scientific reports·2022
Same author

[Early Pulmonary Rehabilitation after Long Term Mechanical Ventilation].

Pneumologie (Stuttgart, Germany)·2021
Same author

Pneumologie (Stuttgart, Germany)·2021
Same author

Pneumologie (Stuttgart, Germany)·2020
Same author

[The Role of Air Pollutants for Health - A Reply to the Expert Opinion of the International Society for Environmental Epidemiology (ISEE) and the European Respiratory Society (ERS)].

Pneumologie (Stuttgart, Germany)·2019
Same author

[Tremendous Increase of Home Care in Ventilated and Tracheostomized Patients - Reasons, Consequences, Solutions].

Pneumologie (Stuttgart, Germany)·2019

Area of Science:

  • Pharmacology
  • Respiratory Medicine
  • Drug Delivery Systems

Background:

  • Polypeptide drugs require alternative administration routes due to proteolytic degradation and first-pass metabolism.
  • Pulmonary drug delivery via aerosols presents an efficient alternative to parenteral (needle) administration.
  • Existing challenges include dose variability, low drug inhalation efficiency, potential allergic reactions, and inconsistent systemic absorption.

Purpose of the Study:

  • To evaluate the potential of aerosolized drug delivery as a viable alternative to traditional administration methods.
  • To address and mitigate the challenges associated with pulmonary drug administration.
  • To explore the safety and efficacy of aerosols for systemic drug treatment.

Main Methods:

  • Development of advanced aerosol delivery systems with controlled particle size and improved nebulization.
  • Implementation of specific inhalation maneuvers, such as slow vital capacity inhalation.
  • Review of studies on the inhalation of various drugs (e.g., insulin, heparin, ribavirin) and their systemic transport.
  • Analysis of factors influencing drug transport across the respiratory tract, including specific diseases and environmental exposures.

Main Results:

  • New aerosol systems demonstrate improved dose accuracy and reproducibility.
  • Nebulization technologies enhance the amount of drug delivered.
  • Studies indicate a low incidence of allergic reactions with inhaled polypeptides and other drugs.
  • Research highlights specific conditions (e.g., active smoking, certain lung diseases) that significantly impact drug absorption.

Conclusions:

  • Aerosolized drug delivery is emerging as a promising alternative to syringe-based administration for systemic treatments.
  • Advancements in aerosol technology and understanding of respiratory physiology are overcoming previous limitations.
  • Pulmonary drug delivery offers a safe and effective route for systemic drug administration, particularly for polypeptides.

Related Experiment Videos