Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Aerosol therapy in AIDS.

S P Newman1, A K Simonds

  • 1Department of Thoracic Medicine, Royal Free Hospital, London, United Kingdom.

Lung
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

Inhaled pentamidine effectively prevents and treats Pneumocystis pneumonia (PCP) in AIDS patients with minor side effects. Optimal nebulizer systems ensure deep lung delivery for better efficacy.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Offshore pelagic subsidies dominate carbon inputs to coral reef predators.

Science advances·2021
Same author

In-home dementia caregiving is associated with greater psychological burden and poorer mental health than out-of-home caregiving: a cross-sectional study.

Aging & mental health·2021
Same author

The combined diabetes and renal control trial (C-DIRECT) - a feasibility randomised controlled trial to evaluate outcomes in multi-morbid patients with diabetes and on dialysis using a mixed methods approach.

BMC nephrology·2019
Same author

Health-Related Quality Of Life (Hrqol) Of Asian Patients With End-Stage Renal Disease (Esrd) In Singapore.

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research·2016
Same author

Does strabismus surgery improve quality and mood, and what factors influence this?

Eye (London, England)·2016
Same author

Randomised crossover trial of telemonitoring in chronic respiratory patients (TeleCRAFT trial).

Thorax·2016
Same journal

Circulating Adipokines as Diagnostic and Prognostic Markers in Idiopathic Pulmonary Fibrosis.

Lung·2026
Same journal

Nebulised heparin as a treatment for lung diseases: formulation challenges and pulmonary drug delivery strategies.

Lung·2026
Same journal

Social Vulnerability Index is Associated with Increased Risk of Malignancy in Screen-Detected High-Risk Pulmonary Nodules.

Lung·2026
Same journal

Validation Approaches for Cough Monitoring Tools: A Scoping Review.

Lung·2026
Same journal

Serological Profiling and Neuro-Immune Resilience: The Dissociation Between Anti-SARS-CoV-2 Antibodies and Post-Viral Airway Hyperresponsiveness in Pediatric Asthma.

Lung·2026
Same journal

Salvinorin A Alleviates Bleomycin-Induced Pulmonary Fibrosis by Inhibiting M2 Macrophage Polarization and Macrophage-to-Myofibroblast Transition.

Lung·2026
See all related articles

Area of Science:

  • Pulmonology
  • Infectious Diseases
  • Pharmacology

Background:

  • Pneumocystis pneumonia (PCP) is a primary opportunistic infection in Acquired Immunodeficiency Syndrome (AIDS) patients.
  • Inhaled pentamidine is an established treatment and prophylactic agent for PCP.
  • Parenteral administration of pentamidine is associated with significant side effects.

Purpose of the Study:

  • To evaluate the efficacy of inhaled pentamidine for PCP prophylaxis and treatment.
  • To compare the side effect profile of inhaled versus parenteral pentamidine.
  • To identify optimal nebulizer system characteristics for effective pentamidine delivery.

Main Methods:

  • Clinical trials were conducted to assess inhaled pentamidine's efficacy.
  • Side effect incidence was compared between administration routes.

Related Experiment Videos

  • Radioaerosol studies were performed to analyze droplet size and delivery characteristics of nebulizer systems.

    • Main Results:

    • Inhaled pentamidine is effective for PCP prophylaxis and treating mild to moderate episodes.
    • Inhaled pentamidine exhibits a favorable side effect profile compared to parenteral administration.
    • Nebulizer systems delivering smaller droplets ( < 2 microns) enhance alveolar penetration.

    Conclusions:

    • Inhaled pentamidine is a safe and effective option for PCP management in AIDS patients.
    • Nebulizer system selection is critical for optimizing drug delivery and patient outcomes.
    • Targeting alveolar penetration with appropriate nebulizer technology improves inhaled pentamidine therapy.