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Infliximab in paediatric inflammatory bowel disease

Pere Vilar1, Javier Martín de Carpi, Claudia E Acuña

  • 1Paediatric Gastroenterology Section, Hospital Universitari Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain.

Journal of Crohn'S & Colitis
|December 22, 2010
PubMed

Insights

Infliximab is effective for pediatric Crohn

Area of Science:

  • Pediatric Gastroenterology
  • Immunology
  • Inflammatory Bowel Disease

Background:

  • Infliximab is utilized for pediatric Crohn's disease, particularly luminal and fistulous types unresponsive to standard therapies.
  • Its application is expanding in refractory pediatric ulcerative colitis.
  • Evidence suggests comparable efficacy and safety in pediatric versus adult populations.

Purpose of the Study:

  • To evaluate the role and impact of infliximab in managing pediatric inflammatory bowel diseases (IBD).
  • To explore the potential of early infliximab intervention to alter disease trajectory and reduce corticosteroid dependency.
  • To assess infliximab's contribution to mucosal healing and normal development in pediatric IBD patients.

Main Methods:

  • Review of existing literature and clinical data on infliximab use in pediatric IBD.
  • Analysis of efficacy and safety profiles in comparison to adult data.
  • Exploration of infliximab's mechanism as a bridging therapy.

Main Results:

  • Infliximab demonstrates similar efficacy and safety in children and adults with IBD.
  • Early use may reduce steroid requirements and modify the natural history of pediatric IBD.
  • Mucosal healing observed with infliximab may support normal growth and sexual maturation.

Conclusions:

  • Infliximab is a valuable therapeutic option for pediatric Crohn's disease and ulcerative colitis.
  • Early infliximab treatment in pediatric IBD could improve outcomes, including reduced steroid use and enhanced development.
  • Further research into early infliximab use is warranted to optimize pediatric IBD management.

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