Related Experiment Video
Updated: Jun 5, 2026
Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease
Published on: September 20, 2018
Non-adherence to treatment in inflammatory bowel disease in Czech Republic
Petr Cerveny1, Martin Bortlik, Jirí Vlcek
1Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Kralove, Charles University, Prague, Czech Republic.
Insights
A significant portion of inflammatory bowel disease (IBD) patients exhibit intentional non-adherence to treatment, with higher disease activity linked to non-adherent behaviors. Improving patient education and emphasizing maintenance therapy are crucial for better outcomes in Crohn
Area of Science:
- Gastroenterology
- Internal Medicine
- Clinical Pharmacy
Background:
- Inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), requires long-term management.
- Treatment adherence is critical for managing IBD and preventing disease flares.
- Non-adherence can significantly impact treatment efficacy and patient outcomes.
Purpose of the Study:
- To determine the prevalence of overall non-adherence to treatment in patients with Crohn's disease (CD) and ulcerative colitis (UC).
- To identify factors associated with non-adherent behaviors in IBD patients.
Main Methods:
- A questionnaire was administered to 396 IBD patients (210 CD, 186 UC) to assess non-adherent behaviors.
- Factor analysis was employed to analyze the collected data on treatment adherence.
- Patient demographics, disease characteristics, and lifestyle factors were considered.
Main Results:
- Overall intentional non-adherence was reported by 32% of patients.
- 12% discontinued treatment, 19% reduced doses, and 11% occasionally missed medication refills.
- Unintentional non-adherence was reported by 42% of patients, with higher disease activity correlating with non-adherence (τ=0.109, p=0.008).
Conclusions:
- Intentional non-adherence is prevalent among IBD patients and warrants clinical attention.
- Enhanced patient education and reinforcement of maintenance therapy importance are recommended.
- Gastroenterologists should actively address non-adherence to optimize IBD management.
Objective:
: To assess overall non-adherence to the treatment among patients with Crohn's disease (CD) and ulcerative colitis (UC).
Patients And Methods:
: 396 inflammatory bowel disease (IBD) patients were enrolled in the study (200 males, 196 females, 210 CD, 186 UC) and fulfilled the questionnaire to assess their non-adherent behaviour during the treatment. The data was analysed using factor analysis.
Results:
: Overall intentional non-adherence was reported by 32% of patients. A 12% of patients reported they at least once discontinued the treatment. Voluntary dose reducing was reported by 19% of patients. An 11% of patients occasionally non-refill the medication in time. There were no differences in intentional adherence between males and females, disease type, previous bowel surgery, marital, smoking and non-smoking statuses. A 42% of patients reported unintentional non-adherence. Factor analysis proved non-adherent patients are more likely to have a higher activity of the disease ( τ=0.109, p=0.008).
Conclusions:
: The overall intentional non-adherence is relatively high among IBD patients and a gastroenterologist's attention should be focused on it. Our results stimulate discussion how to improve education of the patients with inflammatory bowel disease and accent importance of the maintenance therapy to them.
Related Concept Videos
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
01:20Inflammatory Bowel Disease II: Ulcerative Colitis
01:30Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
01:24Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF