Related Experiment Video

Updated: Jun 5, 2026

Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

Familial cases of glomerulonephritis complicating Crohn's disease

L Kallel1, N Nijaa, L Ben Fatma

  • 1Department of Gastroenterology A, Rabta Hospital Tunis, Tunisia.

Journal of Crohn'S & Colitis
|December 22, 2010
PubMed

Insights

This study highlights a rare familial occurrence of glomerulonephritis in Crohn's disease patients, suggesting a potential genetic link for extra-intestinal manifestations. Further research into genetic factors influencing these manifestations is warranted.

Area of Science:

  • Nephrology
  • Gastroenterology
  • Genetics

Background:

  • Renal involvement, especially glomerulonephritis, is uncommon in Crohn's disease (CD).
  • The genetic and environmental influences on CD's extra-intestinal manifestations (EIMs) are not well understood.
  • Familial clustering of EIMs may indicate a genetic predisposition.

Purpose of the Study:

  • To report a familial case of glomerulonephritis in mother and daughter with Crohn's disease.
  • To explore the potential genetic influence on extra-intestinal manifestations in Crohn's disease.

Main Methods:

  • Case report of a 38-year-old woman and her 59-year-old mother with Crohn's disease.
  • Clinical evaluation including peripheral edema, nephrotic syndrome, renal function tests, and abdominal sonography.
  • Renal biopsy in one patient revealing membranous glomerulonephritis.

Main Results:

  • Both patients presented with nephrotic syndrome and peripheral edema during their Crohn's disease course.
  • One patient developed renal failure, while the other maintained preserved renal function.
  • Renal biopsy confirmed membranous glomerulonephritis in one patient.

Conclusions:

  • This familial case suggests a possible genetic link between Crohn's disease and glomerulonephritis.
  • Genetic factors may play a significant role in the development of extra-intestinal manifestations in Crohn's disease.
  • Further investigation into the genetic underpinnings of CD-associated glomerulonephritis is recommended.

More Related Videos

Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis09:44

Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis

Published on: October 14, 2025

Related Concept Videos

Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab (Humira),...
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...
Nephrons01:10

Nephrons

The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma happens...