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Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...
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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle layer, the vascular tunic,...
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Related Experiment Video

Updated: Jun 5, 2026

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients
12:23

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

Published on: April 14, 2014

Visual abnormalities associated with enhanced optic nerve myelination.

Minzhong Yu1, S Priyadarshini Narayanan, Feng Wang

  • 1Department of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA. yum@ccf.org

Brain Research
|December 22, 2010
PubMed
Summary
This summary is machine-generated.

Overexpressing Akt in oligodendrocytes enhances central nervous system myelination, leading to thicker optic nerves in mice. While initially improving visual evoked potential (VEP) speed, prolonged Akt activation later delays VEP latencies.

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Area of Science:

  • Neuroscience
  • Cell Biology
  • Biochemistry

Background:

  • Oligodendrocytes are crucial for central nervous system (CNS) myelination.
  • The serine/threonine kinase Akt plays a role in cellular growth and survival.
  • Constitutively active Akt expression in oligodendrocytes has been linked to enhanced myelination.

Purpose of the Study:

  • To investigate the impact of Akt overexpression on optic nerve structure and function.
  • To assess the effects of enhanced myelination on visual evoked potentials (VEPs).

Main Methods:

  • Generation of transgenic mice (Plp-Akt-DD) with Akt overexpression in oligodendrocytes.
  • Anatomical analysis of optic nerves using electron microscopy.
  • Assessment of optic nerve function via VEP recordings at various ages.
  • Evaluation of retinal function using electroretinography (ERG).

Main Results:

  • Plp-Akt-DD mice exhibited significantly thicker optic nerves with increased myelin thickness.
  • Electron microscopy revealed extended paranodal domains and reduced nodes of Ranvier density.
  • Young Akt-DD mice showed shorter VEP implicit times, suggesting faster nerve conduction.
  • Older Akt-DD mice displayed delayed VEP latencies, despite increased myelination.
  • Retinal function remained unaffected, as indicated by normal ERG results.

Conclusions:

  • Akt overexpression in oligodendrocytes promotes CNS myelination and increases optic nerve thickness.
  • Enhanced myelination initially improves optic nerve conduction but can lead to functional deficits with age.
  • The study highlights the complex role of Akt in regulating myelination and optic nerve function over time.