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Updated: Jun 5, 2026

Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase
Published on: April 29, 2010
DNA replication: making two forks from one prereplication complex
Michael Botchan1, James Berger
1Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA. mbotchan@berkeley.edu
Abstract:
The copying of chromosomal DNA initiates from a single nucleoprotein assembly called the prereplication complex. New findings in a recent issue of Molecular Cell (Yardimci et al., 2010) reveal that this complex dissolves into two independent replisomes that move away from each other as DNA synthesis ensues.
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