Related Experiment Video
Updated: Jun 5, 2026
Closure of a Patent Foramen Ovale (PFO): An Intervention Sequence
Published on: December 23, 2022
Long-term outcome of coil occlusion in patients with patent ductus arteriosus
Hidemi Takata1, Takashi Higaki, Hisashi Sugiyama
1Department of Pediatric Cardiology, Stroke & Cardiovascular Center, Ehime University, Ehime, Japan. hidemi.takata@gmail.com
Insights
Coil occlusion is an effective treatment for patent ductus arteriosus (PDA), with high long-term success rates and minimal adverse events. This study confirms promising outcomes for PDA patients undergoing coil occlusion.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
- Pediatric Cardiology
Background:
- Coil occlusion is a common method for closing patent ductus arteriosus (PDA).
- While generally effective and safe, long-term outcomes of coil occlusion for PDA require further investigation.
- This study focuses on the long-term results of coil occlusion in Japanese PDA patients.
Purpose of the Study:
- To evaluate the long-term efficacy and safety of coil occlusion for patent ductus arteriosus (PDA).
- To identify factors influencing the success rate and potential complications of PDA coil occlusion.
Main Methods:
- Analysis of longitudinal data from 298 patients who underwent 310 coil occlusions for PDA between 1995 and 2009.
- Assessment of occlusion rates, residual leakage, and adverse events over a median follow-up of 50 months.
- Comparison of outcomes based on PDA size and procedural timing (early vs. late study period).
Main Results:
- Successful coil occlusion was achieved in 96.0% of patients, with a low overall adverse event rate of 9.0%.
- High occlusion rates were sustained long-term (97.8% at 5 years).
- Larger PDA size (≥4mm) and earlier procedural timing were associated with a higher rate of residual leakage.
Conclusions:
- Coil occlusion is a highly effective procedure for managing patent ductus arteriosus (PDA).
- The long-term outcomes for PDA patients treated with coil occlusion are promising.
- Factors like PDA size and procedure timing may influence residual leakage, suggesting potential areas for improved patient selection or technique.
Background:
Coil occlusion has been widely indicated for the closure of patent ductus arteriosus (PDA). Although many reports have shown the efficacy and safety of coil occlusion, the long-term outcome in patients remains controversial. Here, we analyzed the long-term outcome of coil occlusion in patients with PDA in Japan.
Methods And Results:
We collected the longitudinal data of patients who underwent coil occlusion between 1995 and 2009. A total of 310 coil occlusions were performed in 298 patients with PDA. The median minimum duct diameter was 1.4mm. Successful coil occlusion was achieved in 286 patients (96.0%), and total adverse events were seen in only 28 cases (9.0%). The median follow-up period was 50 months. The occlusion rates at 1 month, 6 months, 1 year, 2 years and 5 years were 90.1%, 94.4%, 97.4%, 97.8% and 97.8%, respectively. Patients with a large PDA (≥4mm) showed a higher rate of residual leakage than those with a small (<2mm) or moderate (2-4mm) PDA (P=0.004). Patients who underwent this procedure in the early study period also showed a higher rate of residual leakage than those in the late study period.
Conclusions:
Coil occlusion is an effective procedure for patients with PDA. Our data indicate that the long-term outcome is promising without any adverse events.
