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Updated: Jun 5, 2026
09:10
Palatable Western-style Cafeteria Diet as a Reliable Method for Modeling Diet-induced Obesity in Rodents
Published on: November 1, 2019
Diet, obesity and cancer
J V Reynolds1, C L Donohoe, S L Doyle
1Department of Surgery, Trinity Centre for Health Sciences, Trinity College Dublin/St. James' Hospital, Dublin 8, Ireland. reynoljv@tcd.ie
Irish Journal of Medical Science
|December 22, 2010
Summary
Diet and lifestyle significantly impact cancer development and progression. This review highlights how specific dietary compounds influence cancer mechanisms, offering potential targets for prevention and treatment.
Area of Science:
- Oncology
- Nutritional Science
- Environmental Health
Background:
- Obesity and lifestyle factors are linked to increased cancer incidence.
- Environmental influences play a critical role in cancer development.
- Dietary patterns are complex and interact with various factors in cancer etiology.
Purpose of the Study:
- To review current evidence on dietary factors and their association with cancer incidence and progression.
- To explore the mechanisms through which diet influences tumorigenesis.
- To identify challenges and future directions in diet-cancer research.
Main Methods:
- Literature search of the PubMed database using keywords: diet, cancer, carcinogenesis, tumourigenesis.
- Review of relevant articles and their references.
- Prioritization of meta-analyses of randomized controlled trials (RCTs) or large RCTs where available.
Main Results:
- Geographic variations and migration studies indicate environmental factors, including diet, are key to cancer incidence.
- Dietary constituents like glucosinolates, organosulphur compounds, genistein, curcumin, catechins, resveratrol, and lycopene may influence tumorigenesis mechanisms (e.g., inflammation, angiogenesis).
Conclusions:
- Epidemiological evidence links diet to cancer, but confounding factors (obesity, physical activity, dietary complexity) present research challenges.
- Understanding the interplay of dietary compounds and cancer development is crucial for identifying new prevention and treatment targets.
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