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Updated: Jun 5, 2026
A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis
Published on: January 7, 2018
Resibufogenin administration prevents oxidative stress in a rat model of human preeclampsia
Mohammad Nasir Uddin1, Enoch E Agunanne, Darijana Horvat
1Department of Medicine, Division of Nephrology and Hypertension, Texas A&M Health Science Center College of Medicine and Scott & White Memorial Hospital, Temple, TX, USA.
Background And Objectives:
Marinobufagenin (MBG) is a cardiotonic steroid that is increased in preeclampsia. An analog of MBG, resibufogenin (RBG), prevents the development of preeclampsia in a rat model. Oxidative stress is a concomitant of endothelial dysfunction in the latter disorder. The objective of the current studies was to evaluate the status of oxidative stress in a rat model of preeclampsia.
Methods:
We measured the aortic AT(1) receptor expression and urinary excretion of 8-isoprostane (8IP) in rats rendered "preeclamptic" and compared the findings to those obtained in normal pregnant animals, pregnant rats injected with MBG, and preeclamptic rats treated with RBG.
Results:
Aortic AT(1) receptor expression and the urinary excretion of 8IP were significantly augmented in "preeclamptic" and MBG-injected pregnant rats compared to normal pregnant animals. RBG prevented evidence of oxidative stress in "preeclamptic" rats.
Conclusion:
MBG is involved in the causation of oxidative stress in our rat model and RBG attenuates this change.
