Gestational diabetes or lesser degrees of glucose intolerance and risk of preeclampsia
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Published on: January 26, 2024
Darcy B Carr1, Katherine M Newton, Kristina M Utzschneider
1Division of Maternal-Fetal Medicine, Department of Obstetrics & Gynecology, University of Washington, Seattle, WA 98195, USA. darcarr@u.washington.edu
Objective:
We evaluated the association of 1-h oral glucose challenge test (OGCT) and 3-h oral glucose tolerance test (OGTT) results with preeclampsia.
Methods:
A retrospective cohort study was performed among 26,105 women.
Results:
Preeclampsia was associated with the upper OGCT quartiles [114-132 mg/dL: odds ratio (OR) = 1.25, 95% confidence interval (CI) 1.09-1.44; >132 mg/dL: OR = 1.40, 95% CI 1.21-1.61] compared with <98 mg/dL adjusting for age, primigravidity, and gestational diabetes, and also to one abnormal OGTT value (adjusted OR 1.38, 95% CI 1.09-1.75) or gestational diabetes (adjusted OR 1.45, 95% CI 1.15-1.83).
Conclusion:
Higher glucose levels are associated with preeclampsia suggesting a pathophysiological role for glucose metabolism.
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