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Separating Beads and Cells in Multi-channel Microfluidic Devices Using Dielectrophoresis and Laminar Flow

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Published on: February 4, 2011

Experimental optimization of flow distributors for pressure-driven separations and reactions in flat-rectangular

Joris Vangelooven¹, Stefan Schlautman, Frederik Detobel

¹Department of Chemical Engineering (Transport Modelling & Analytical Separation Science-group), Vrije Universiteit Brussel, Brussels, Belgium.

Analytical Chemistry

|December 24, 2010

Summary

Optimized microfabricated flow distributors improve separations and reactions. Radially interconnected designs with diamond pillars and specific divergence angles yield the best performance in flat channels.

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Assembly and Characterization of an External Driver for the Generation of Sub-Kilohertz Oscillatory Flow in Microchannels

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Published on: January 28, 2022

Area of Science:

Microfluidics
Chemical Engineering
Materials Science

Background:

Microfabricated flow distributors are crucial for pressure-driven separations and reactions in microfluidic devices.
Optimizing distributor design is essential for enhancing efficiency and preventing issues like band broadening and dead zones.

Purpose of the Study:

To experimentally optimize the design of microfabricated flow distributors for flat-rectangular channels.
To identify key design parameters influencing flow distribution uniformity and performance.

Main Methods:

Fabrication of various flow distributor designs in glass/silicon wafers.
Experimental comparison of distributor performance using CCD camera detection.
Analysis of band shape and variance to quantify elution characteristics.

Main Results:

Radially interconnected distributors with diverging inlets and diamond-shaped pillars showed superior performance.
Optimal designs feature 10-12 rows of high aspect ratio pillars followed by regions with smaller pillars.
Specific divergence angles and the use of distributor wedges minimize dead zones and improve flow uniformity.

Conclusions:

The study successfully identified optimal design principles for microfluidic flow distributors.
The findings enable the development of more efficient microfluidic systems for separations and reactions.
The optimized designs contribute to improved control over fluid dynamics in microchannels.